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The Design of Polyvalent Therapeutics
Author(s) -
Joshi Amit,
Vance David,
Rai Prakash,
Thiyagarajan Aditya,
Kane Ravi S.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800278
Subject(s) - drug delivery , nanotechnology , medicine , materials science
This article reviews recent developments in the design of polyvalent ligands for in vivo applications. Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or suppressing immune responses.