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Asymmetric Total Synthesis of PDIM A: A Virulence Factor of Mycobacterium tuberculosis
Author(s) -
CasasArce Eva,
ter Horst Bjorn,
Feringa Ben L.,
Minnaard Adriaan J.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800243
Subject(s) - mycobacterium tuberculosis , virulence , microbiology and biotechnology , virulence factor , tuberculosis , mycobacterium , bacteria , biology , chemistry , medicine , gene , biochemistry , pathology , genetics
An array of efficient catalytic transformations has been employed for the first stereoselective total synthesis of the lipid phthiocerol dimycocerosate A (PDIM A). It has been shown previously that this cell‐wall‐associated lipid, the structure of which has now been confirmed, is required for Mycobacterium tuberculosis virulence.