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General Synthesis and Aggregation Behaviour of New Single‐Chain Bolaphospholipids: Variations in Chain and Headgroup Structures
Author(s) -
Drescher Simon,
Meister Annette,
Graf Gesche,
Hause Gerd,
Blume Alfred,
Dobner Bodo
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800033
Subject(s) - differential scanning calorimetry , micelle , chemistry , transmission electron microscopy , chain (unit) , single chain , crystallography , polar , amphiphile , chemical engineering , nanotechnology , polymer chemistry , polymer , materials science , organic chemistry , copolymer , aqueous solution , physics , thermodynamics , astronomy , biology , antibody , engineering , immunology
The chemical structures of polymethylene‐1,ω‐bis(phosphocholines) that self‐assemble into nanofibres was modified on the one hand in the hydrophobic chain region, by introduction of sulfur and oxygen atoms, and on the other hand by variation of the polar headgroup structure with functionalised tertiary amines. The temperature‐dependent self‐assembly of these novel bolaphospholipids into nanofibres and spherical micelles was investigated by differential scanning calorimetry (DSC) and transmission electron microscopy (TEM). The thermal stabilities of the nanofibres strongly depend on the chemical compositions of the headgroups and of the hydrophobic chains. The insertion of new functionalities in the headgroup region by click chemistry makes these substances interesting for potential applications in bioscience and materials science.