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New Strategies for the Synthesis of Pyrimidine Derivatives
Author(s) -
Hill Matthew D.,
Movassaghi Mohammad
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200800014
Subject(s) - pyrimidine , intramolecular force , condensation , combinatorial chemistry , chemistry , fragment (logic) , stereochemistry , computer science , programming language , physics , thermodynamics
Abstract Recent advances in pyrimidine synthesis are described. Modification of conventional strategies involving N‐C‐N fragment condensation with 1,3‐dicarbonyl derivatives remains a common theme in current literature. Other methods, including N–C fragment condensation strategies, provide reactive intermediates capable of intramolecular cyclization and formation of pyrimidine derivatives. These recently developed methodologies offer a valuable addendum to azaheterocycle synthesis.