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Cover Picture: Improved Cyclodextrin‐Based Receptors for Camptothecin by Inverse Virtual Screening (Chem. Eur. J. 24/2007)
Author(s) -
Steffen Andreas,
Thiele Carolin,
Tietze Simon,
Strassnig Christian,
Kämper Andreas,
Lengauer Thomas,
Wenz Gerhard,
Apostolakis Joannis
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200790088
Subject(s) - camptothecin , virtual screening , cyclodextrin , chemistry , binding affinities , combinatorial chemistry , receptor , drug , computer science , computational biology , pharmacology , drug discovery , biochemistry , biology
Design of a synthetic receptor for a given ligand, in this case the anti‐cancer drug camptothecin, is generally a very tedious task. Many receptor candidates have to be synthesized and checked to find a few hits with high affinities. Therefore it is more efficient to perform the most part of receptor screening in the virtual space of a computer as visualized on the cover picture. In their Full Paper on page 6801 ff., G. Wenz, J. Apostolakis et al. demonstrate that the resulting top‐ranking candidates, derivatives of β‐cyclodextrin, indeed exhibit exceptional binding potential for camptothecin and are promising excipients for drug delivery.