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1,2‐Alkyl Migration as a Key Element in the Invention of Cascade Reactions Catalyzed by π‐Acids
Author(s) -
Crone Benedikt,
Kirsch Stefan F.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200701985
Subject(s) - alkyl , cascade , catalysis , chemistry , combinatorial chemistry , organic chemistry , chromatography
This brief overview highlights recent progress in the field of cascade reactions that are initiated by the activation of a π‐system using platinum and gold catalysts and that are coupled with a 1,2‐alkyl migration step. While the reactions discussed aim to rapidly evolve molecular complexity, they are experimentally straightforward and easy to perform. Primarily guided by the type of 1,2‐alkyl migration, methods are categorized as shifts to metal carbenoid centers and pinacol‐type rearrangements.