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Complexation of L ‐Lactate with Boronic Acids: A Solution and Holographic Analysis
Author(s) -
Sartain Felicity K.,
Yang Xiaoping,
Lowe Christopher R.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200701911
Subject(s) - boronic acid , chemistry , acrylamide , receptor , combinatorial chemistry , biochemistry , organic chemistry , polymer , copolymer
Boronic acids have been used as receptors for the detection of diols and α‐hydroxy acids. The incorporation of 3‐acrylamide phenyl boronic acid (3‐APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L ‐lactate. However, it was also found that the use of 3‐APB resulted in the sensor being responsive towards a number of other compounds containing two hydroxy groups. This report details the further investigation into the reaction between L ‐lactate and three boronic acid‐based receptors, both in the holograms and in solution, in order to establish the mechanism of binding. A novel boronate receptor is proposed based on this understanding.