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The Search for a Potentially Prebiotic Synthesis of Nucleotides via Arabinose‐3‐phosphate and Its Cyanamide Derivative
Author(s) -
Anastasi Carole,
Buchet Fabien F.,
Crowe Michael A.,
Helliwell Madeleine,
Raftery Jim,
Sutherland John D.
Publication year - 2008
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200701351
Subject(s) - nucleotide , phosphate , rna , prebiotic , cyanamide , chemistry , derivative (finance) , pyrimidine , biochemistry , sugar phosphates , combinatorial chemistry , financial economics , economics , gene
For the RNA world hypothesis to be accepted, the constitutional self‐assembly of RNA will have to be demonstrated. Conceptually, the simplest route to RNA involves nucleotide polymerisation. Activated pyrimidine nucleotides can be derived from arabinose‐3‐phosphate under potentially prebiotic conditions, but the prebiotic synthesis of this sugar phosphate has not hitherto been investigated. The results of synthetic approaches involving phosphorylation, phosphate migration and 2,3‐CC bond construction are described herein.