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Recent Advances in the Benzannulation of Substituted 3‐Alkoxycarbonyl‐3,5‐hexadienoic Acids and 3‐Alkoxycarbonylhex‐3‐en‐5‐ynoic Acids to Polysubstituted Aromatics
Author(s) -
Serra Stefano,
Fuganti Claudio,
Brenna Elisabetta
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200700735
Subject(s) - chemistry , medicinal chemistry , organic chemistry , combinatorial chemistry
The benzannulation reactions of substituted 3‐alkoxycarbonyl‐3,5‐hexadienoic and 3‐alkoxycarbonylhex‐3‐en‐5‐ynoic acids offer a straightforward access to various polysubstituted aromatic compounds. The process is very flexible, and can be applied to the regiospecific preparation of oligoaryls, naphthalenes, ring‐fused heterocycles, chiral tetrahydronaphthalenes, C ‐aryl‐glycosides and many natural products of different structure. In this Concept article, we highlight the potential of this annulation reaction by illustration of our recent contribution to this field, as well as the studies previous reported by others.