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Overcoming the Demons of Protecting Groups with Amphoteric Molecules
Author(s) -
Yudin Andrei K.,
Hili Ryan
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200700710
Subject(s) - chemoselectivity , functional group , protecting group , molecule , combinatorial chemistry , group (periodic table) , chemistry , nanotechnology , biochemical engineering , organic chemistry , engineering , materials science , catalysis , polymer , alkyl
Synthetic organic chemists have long depended on protecting group manipulations when faced with the challenges of chemoselectivity and functional group incompatibility. Overcoming this dependence will improve the overall efficiency of chemical synthesis. By taking advantage of orthogonally reactive functional groups, amphoteric molecules can afford access not only to more efficient and strategic syntheses but also to the development of novel chemical transformations.