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Atom‐Transfer Radical Addition (ATRA) and Cyclization (ATRC) Reactions Catalyzed by a Mixture of [RuCl 2 Cp*(PPh 3 )] and Magnesium
Author(s) -
Thommes Katrin,
Içli Burçak,
Scopelliti Rosario,
Severin Kay
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200700442
Subject(s) - ruthenium , catalysis , magnesium , chemistry , atom (system on chip) , reducing agent , medicinal chemistry , combinatorial chemistry , organic chemistry , computer science , embedded system
A new catalytic procedure for atom‐transfer radical addition (ATRA) and cyclization (ATRC) reactions is described. The combination of the ruthenium(III) complex [RuCl 2 Cp*(PPh 3 )] (Cp*: pentamethylcyclopentadienyl) with magnesium allows these reactions to be performed under mild conditions with high efficiency. In most cases, the catalyst concentrations required are significantly lower than those used in previously reported procedures. It is suggested that magnesium acts as a reducing agent that generates and regenerates the catalytically active ruthenium(II) species. The precatalyst [RuCl 2 Cp*(PPh 3 )] has been analyzed by X‐ray crystallography.