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Multifunctionalization of Dendrimers through Orthogonal Transformations
Author(s) -
Goyal Poorva,
Yoon Kunsang,
Weck Marcus
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200700129
Subject(s) - dendrimer , moiety , surface modification , combinatorial chemistry , hydrazide , polyamide , alkyne , aldehyde , chemistry , nanotechnology , materials science , organic chemistry , catalysis
A straightforward methodology for the synthesis of multifunctionalized dendrimers that is based on an orthogonal functionalization strategy has been developed. Polyamide‐based dendrimers that possess both a single aldehyde and a single azide moiety on their periphery have been synthesized by using a convergent synthetic strategy. These dendrimers can be functionalized quantitatively with small organic and biological molecules that contain hydrazide and/or alkyne groups in which each functional moiety is completely specific for its complementary motif. This orthogonal functionalization strategy has the potential to be used to synthesize multifunctional dendrimers for a variety of applications, which range from targeted biological delivery vehicles to optical materials.