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A State‐of‐the‐Art Cyanation of Aryl Bromides: A Novel and Versatile Copper Catalyst System Inspired by Nature
Author(s) -
Schareina Thomas,
Zapf Alexander,
Mägerlein Wolfgang,
Müller Nikolaus,
Beller Matthias
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200700079
Subject(s) - cyanation , reagent , aryl , catalysis , cyanide , copper , combinatorial chemistry , chemistry , halide , substrate (aquarium) , selectivity , ligand (biochemistry) , organic chemistry , biochemistry , alkyl , oceanography , receptor , geology
Abstract A general protocol for the cyanation of aryl halides with the nontoxic cyanide source K 4 [Fe(CN) 6 ] using copper catalysis and a ligand system based on 1‐alkylimidazoles is presented. The advantages of this system are the high selectivity, a unique substrate range, easy handling, and inexpensive reagents.