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Design of Original Bioactive Formulations Based on Sugar–Surfactant/Non‐steroidal Anti‐inflammatory Catanionic Self‐Assemblies: A New Way of Dermal Drug Delivery
Author(s) -
Consola Sabrina,
Blanzat Muriel,
Perez Emile,
Garrigues JeanChristophe,
Bordat Pascal,
RicoLattes Isabelle
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200601449
Subject(s) - vesicle , pulmonary surfactant , ibuprofen , ketoprofen , chemistry , drug delivery , drug , in vivo , pharmacology , chromatography , organic chemistry , biochemistry , medicine , membrane , microbiology and biotechnology , biology
A new kind of catanionic assembly was developed that associates a sugar‐based surfactant with a non‐steroidal anti‐inflammatory drug (NSAID). Three different assemblies using indomethacin, ibuprofen and ketoprofen as NSAIDs were easily obtained in water by an acid–base reaction. These assemblies formed new amphiphilic entities because of electrostatic and hydrophobic effects in water and led to the spontaneous formation of vesicles. These catanionic vesicles were then tested as potential NSAID delivery systems for dermatological application. The anti‐inflammatory activity was evaluated in vivo, and this study clearly showed an improved therapeutic effect for NSAIDs that were formulated as catanionic vesicles. These vesicles ensured a slower diffusion of the NSAID through the skin. This release probably increased the time of retention of the NSAID in the targeted strata of the skin. Thus, the present study suggests that this catanionic bioactive formulation could be a promising dermal delivery system for NSAIDs in the course of skin inflammation treatment.