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A Fluorous, Pummerer Cyclative‐Capture Strategy for the Synthesis of N‐Heterocycles
Author(s) -
McAllister Laura A.,
McCormick Rosemary A.,
James Karen M.,
Brand Stephen,
Willetts Nigel,
Procter David J.
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200601429
Subject(s) - pummerer rearrangement , computer science , chemistry , combinatorial chemistry , organic chemistry , catalysis , acetic anhydride
A fluorous, cyclative‐capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd‐catalyzed cross‐couplings is possible. Traceless, reductive cleavage of the fluorous‐phase tag or oxidative cleavage and further elaboration, completes a strategy for the high‐throughput, fluorous‐phase synthesis of a diverse range of N‐heterocycles.