A Fluorous, Pummerer Cyclative‐Capture Strategy for the Synthesis of N‐Heterocycles

A fluorous, cyclative‐capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd‐catalyzed cross‐couplings is possible. Traceless, reductive cleavage of the fluorous‐phase tag or oxidative cleavage and further elaboration, completes a strategy for the high‐throughput, fluorous‐phase synthesis of a diverse range of N‐heterocycles.