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Receiver–Amplifier, Self‐Immolative Dendritic Device
Author(s) -
Amir Roey J.,
Danieli Eyal,
Shabat Doron
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200601263
Subject(s) - dendrimer , chemistry , cleavage (geology) , biophysics , fluorescence , materials science , biochemistry , biology , physics , quantum mechanics , fracture (geology) , composite material
Self‐immolative dendrimers disassemble through a domino‐like chain fragmentation initiated by a single cleavage at the dendrimer core. We have designed and synthesized dendritic molecules that resemble dendritic architectures present in nature. The unique design allows a cleavage signal received by any one of the multiple triggers on one side of the dendrimer to be transferred convergently to a focal point. The signal is divergently amplified through to the other side of the dendrimer, reporter units are released, and fluorescence is emitted. During signal propagation, the dendritic molecule disassembles in a self‐immolative manner into small fragments. These compounds are the longest dendritic system ever reported to disassemble through sequential self‐immolative reactions. The synthesized dendritic molecules have an architecture and signal‐conducting activity related to that of neurons.