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Extraction of Radio‐Labelled Xanthine Derivatives by Artificial Receptors: Deep Insight into the Association Behaviour
Author(s) -
Bomkamp Martin,
Siering Carsten,
Landrock Karin,
Stephan Holger,
Fröhlich Roland,
Waldvogel Siegfried R.
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200601231
Subject(s) - toluene , dichloromethane , chemistry , extraction (chemistry) , receptor , solvent , molecule , xanthine , chromatography , organic chemistry , biochemistry , enzyme
Association constants for the interaction of almost insoluble substrates with triphenylene ketal‐based receptors in toluene have been determined by means of an extraction method employing the corresponding radio‐labelled substrates. Flexible and more polar receptors tend to aggregate and exhibit inferior extraction qualities. Binding constants in toluene were found to be in the range 10 5 –10 7 m −1 , which is significantly higher than in dichloromethane. X‐ray analyses indicate the direct participation of a water molecule in the binding process, which may account for the surprisingly small effect of moisture in the solvent on the stability of the complexes.