Premium
Highly Efficient and Functional‐Group‐Tolerant Catalysts for the Palladium‐Catalyzed Coupling of Aryl Chlorides with Thiols
Author(s) -
FernándezRodríguez Manuel A.,
Shen Qilong,
Hartwig John F.
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200600949
Subject(s) - palladium , functional group , aryl , catalysis , chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , materials science , polymer , metallurgy , alkyl
The cross‐coupling reaction of aryl chlorides with aliphatic and aromatic thiols catalyzed by palladium complexes of the strongly binding bisphosphine CyPF‐ t Bu ligand ( 1 ) is reported. Most of the reactions catalyzed by complexes of ligand 1 occur with turnover numbers that exceed those of previous catalysts by two orders of magnitude. The reactions occur with excellent yields, broad scope and high tolerance of functional groups. Coupling of aryl halides with thiols in the presence of low loadings of catalysts derived from other Josiphos type ligands, as well as ligands of other structural types, are also described.