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DyNAs: Constitutional Dynamic Nucleic Acid Analogues
Author(s) -
Sreenivasachary Nampally,
Hickman David T.,
Sarazin Dominique,
Lehn JeanMarie
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200600625
Subject(s) - cationic polymerization , polynucleotide , polymer , nucleic acid , polymerization , monomer , chemistry , nucleobase , polymer chemistry , condensation polymer , nuclear magnetic resonance spectroscopy , combinatorial chemistry , organic chemistry , dna , biochemistry
Dynamic cationic polymers were generated in aqueous media from functionally complementary monomers bearing nucleobase groups. 1 H NMR spectroscopy was used to follow the polycondensation reaction of the nucleobase‐appended dihydrazides 1 and 2 with the dialdehydes B and C . The reversibility of these polymers was established by proton NMR spectroscopy through exchange of the dihydrazide 2 with polymer 1 B . The polymers 1 B , 2 B , 1 C , and 2 C represent dynamic biopolymers of nucleic acid type, DyNAs. Electrostatic interaction of these polymers with polyanionic entities, such as polyphosphates, polynucleotides, and polyaspartic acid, was shown to take place. It induces a change in size of the dynamic polymer, as it responds by an increase in degree of polymerization to an increase of the overall anionic charge introduced, that is, to the total electrostatic interaction.