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Nanostructured Thermosensitive Polymers with Radical Scavenging Ability
Author(s) -
Zhou Guangchang,
Harruna Issifu I.,
Zhou Weilie L.,
Aicher Wilhelm K.,
Geckeler Kurt E.
Publication year - 2007
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200600590
Subject(s) - azobisisobutyronitrile , chain transfer , raft , chemistry , polymer chemistry , radical , radical polymerization , polymer , polymerization , size exclusion chromatography , reversible addition−fragmentation chain transfer polymerization , poly(n isopropylacrylamide) , photochemistry , organic chemistry , copolymer , enzyme
The thermosensitive [60]fullerene end‐capped poly( N ‐isopropylacrylamide) was successfully synthesized by the reaction of C 60 with dithiobenzoate‐terminated poly( N ‐isopropylacrylamide), which was prepared by reversible addition‐fragmentation chain‐transfer (RAFT) polymerization in the presence of azobisisobutyronitrile (AIBN). Its structure was determined by FTIR, UV/Vis, and carbon and proton NMR spectroscopy as well as by size exclusion chromatography (SEC). The novel fullerenated polymer retained the thermosensitivity of poly( N ‐isopropylacrylamide). Moreover, it is soluble in water and most of the common organic solvents. Interestingly, it was able to form nanoparticle clusters in methanol and exhibited significant radical scavenging ability in cell viability and metabolic activity tests with fibroblasts and NOR‐3 radicals.