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Probing Structural Effects on Replication Efficiency through Comparative Analyses of Families of Potential Self‐Replicators
Author(s) -
Kassianidis Eleftherios,
Pearson Russell J.,
Philp Douglas
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200600460
Subject(s) - replication (statistics) , template , supramolecular chemistry , autocatalysis , function (biology) , nanotechnology , computer science , biological system , materials science , biology , chemistry , molecule , physics , kinetics , evolutionary biology , organic chemistry , quantum mechanics , virology
A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self‐replication). In order to achieve this goal, a detailed understanding of the relationship between molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally‐related systems reveals the key determinants that dictate the emergence of self‐replicative function and defines the structural space within which this behaviour is observed.