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Combining Enabling Techniques in Organic Synthesis: Continuous Flow Processes with Heterogenized Catalysts
Author(s) -
Kirschning Andreas,
Solodenko Wladimir,
Mennecke Klaas
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200600236
Subject(s) - continuous flow , catalysis , flow (mathematics) , process engineering , materials science , computer science , chemical engineering , chemistry , biochemical engineering , organic chemistry , engineering , mechanics , physics
The concepts article describes enabling techniques (solid‐phase assisted synthesis, new reactor design, microwave irradiation and new solvents) in organic chemistry and emphasizes the combination of several of them for creating new synthetic technology platforms. Particular focus is put on the combination of immobilized catalysts as well as biocatalysts with continuous flow processes. In this context, the PASSflow continuous flow technique fulfils both chemical as well as chemical engineering requirements. It combines reactor design with optimized, monolithic solid phases as well as reversible immobilization techniques for performing small as well as large scale synthesis with heterogenized catalysts under continuous flow conditions.