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An Extremely Stable Host–Guest Complex That Functions as a Fluorescence Probe for Calcium Ions
Author(s) -
Lin ChiFeng,
Liu YiHung,
Lai ChienChen,
Peng ShieMing,
Chiu ShengHsien
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200600090
Subject(s) - supramolecular chemistry , fluorescence , chemistry , ion , crown ether , hydrogen bond , molecule , photochemistry , calcium , host–guest chemistry , inorganic chemistry , organic chemistry , physics , quantum mechanics
Herein, we report a crown ether based molecular cage that forms extremely stable supramolecular complexes with dimethyldiazapyrenium (DMDAP) ions in CD 3 CN through the collaboration of multiple weak CH⋅⋅⋅O hydrogen bonds. The very strong binding affinity in this host–guest system allows the molecular cage to bleach the fluorescence signal of DMDAP substantially in equimolar solutions at concentrations as low as 1×10 −5 M . Remarkably, a 1×10 −5 M equimolar solution of the molecular cage and DMDAP is highly selective toward Ca 2+ ions—relative to other biologically important Li + , Na + , K + , and Mg 2+ ions—and causes a substantial increase in the fluorescence intensity of the solution. As a result, this molecular cage/DMDAP complex behaves as a supramolecular fluorescence probe for the detection of Ca 2+ ions in solution.