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Cover Picture: Artificial Metalloenzymes for Enantioselective Catalysis Based on the Noncovalent Incorporation of Organometallic Moieties in a Host Protein (Chem. Eur. J. 13/2005)
Author(s) -
Ward Thomas R.
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200590041
Subject(s) - enantiopure drug , enantioselective synthesis , biotinylation , catalysis , chemistry , rhodium , combinatorial chemistry , non covalent interactions , streptavidin , click chemistry , stereochemistry , organic chemistry , molecule , biotin , biochemistry , hydrogen bond
Enzymatic and homogeneous catalysis offer complementary means to produce enantiopure products. Incorporation of achiral, biotinylated aminodiphosphine–rhodium complexes in (strept)avidin, which fit to each other as a hand in a glove, affords enantioselective hydrogenation catalysts. A combined chemogenetic procedure that allows the optimization of the activity and the selectivity of such artificial metalloenzymes is described in the Concept article by T. R. Ward on page 3798 ff.