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Cover Picture: A Modular Approach to DNA‐Programmed Self‐Assembly of Macromolecular Nanostructures (Chem. Eur. J. 4/2005)
Author(s) -
Gothelf Kurt V.,
Brown Raymond S.
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200590011
Subject(s) - dna , macromolecule , polymerization , nanotechnology , modular design , dna nanotechnology , self assembly , chemistry , covalent bond , dna origami , conjugated system , coupling (piping) , nanostructure , materials science , combinatorial chemistry , computer science , polymer , biochemistry , organic chemistry , metallurgy , operating system
DNA‐programmed self‐assembly: K. V. Gothelf and R. S. Brown describe new and powerful tools for assembling chemical compounds into predetermined complex structures by using DNA‐programmed organic reactions in their Concepts article on page 1062 ff. This approach is particular efficient for the selection and covalent coupling of multiple components. DNA‐templated synthesis is used for polymerization of PNA tetramers and for copying of the connectivity information in DNA. Direct DNA‐programmed multicomponent coupling of custom designed organic modules is described. The macromolecular structures obtained are highly conjugated potentially conducting nanoscaffolds.