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Organocatalysis Mediated by (Thio)urea Derivatives
Author(s) -
Con Stephen J.
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200501076
Subject(s) - thio , bifunctional , organocatalysis , catalysis , enantioselective synthesis , chemistry , combinatorial chemistry , urea , organic chemistry
Over the last decade the potential for N,N ‐dialkyl(thio)urea derivatives to serve as active metal‐free organocatalysts for a wide range of synthetically useful reactions susceptible to the influence of general acid catalysis has begun to be realised. This article charts the development of these catalysts (with emphasis on the design principles involved), from early “proof‐of‐concept” materials to contemporary active chiral (bifunctional) promoters of highly selective asymmetric transformations.