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A Microcapillary System for Simultaneous, Parallel Microwave‐Assisted Synthesis
Author(s) -
Comer Eamon,
Organ Michael G.
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500820
Subject(s) - microwave , computer science , materials science , telecommunications
A continuous flow, microwave‐assisted, parallel‐capillary microreactor has been developed. Libraries of drug candidates were prepared on the milligram scale with this reactor by injecting plugs of reagents from separate syringes into common reaction capillaries, thereby producing discrete compounds in excellent yield and purity. Microwave irradiation provides the necessary energy that existing room‐temperature microreactor technology lacks for higher activation barrier transformations, producing the required amounts of desired compounds in minutes or less.