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Ir‐Catalysed Asymmetric Hydrogenation: Ligands, Substrates and Mechanism
Author(s) -
Källström Klas,
Munslow Ian,
Andersson Pher G.
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500755
Subject(s) - mechanism (biology) , asymmetric hydrogenation , chemistry , combinatorial chemistry , enantioselective synthesis , noyori asymmetric hydrogenation , stereochemistry , catalysis , organic chemistry , philosophy , epistemology
Relatively air and moisture tolerant cationic iridium complexes, with chiral non‐racemic N,P‐ligands and weakly coordinating counter ions, are efficient catalysts in the asymmetric hydrogenation of olefins. Unfunctionalised olefins are particularly difficult substrates because, in general, a polar group adjacent to the alkene bond is required for high catalytic activity and enantioselectivity. The applicability towards a variety of substrates and choice of ligands reported thus far in the literature, as well as the mechanism, selectivity issues and the importance of the anion are also discussed.