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Preparation, Characterization, and Application of Multistimuli‐Responsive Microspheres with Fluorescence‐Labeled Magnetic Cores and Thermoresponsive Shells
Author(s) -
Deng Yonghui,
Wang Changchun,
Shen Xizhong,
Yang Wuli,
Jin Lan,
Gao Hong,
Fu Shoukuan
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500605
Subject(s) - microsphere , fluorescence , materials science , drug delivery , in vivo , characterization (materials science) , nanotechnology , biophysics , drug , biomedical engineering , magnetic field , chemistry , chemical engineering , optics , pharmacology , medicine , physics , microbiology and biotechnology , engineering , biology , quantum mechanics
Novel functional microspheres with multistimuli‐responsive properties have been prepared and characterized. The as‐prepared microspheres respond to an external magnetic field, environmental temperature, and ultraviolet radiation. The in vitro drug‐loading efficiency and drug‐release behavior of these microspheres demonstrated that they could be used as drug carriers for drug controlled release. The results of in vivo distribution investigations of these microspheres showed that they exhibit a high magnetic‐targeting effect, which holds promise for applications in various fields such as magnetic drug targeting and tissue labeling, among others.