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Exploring and Exploiting the Therapeutic Potential of Glycoconjugates
Author(s) -
Doores Katie J.,
Gamblin David. P.,
Davis Benjamin G.
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500557
Subject(s) - glycoconjugate , intracellular , immune system , cell , cell signaling , microbiology and biotechnology , glycoprotein , biology , glycolipid , computational biology , glycopeptide , signal transduction , chemistry , biochemistry , immunology , antibiotics
Carbohydrates, either bound to proteins or in lipids, play essential roles as communication molecules in many intercellular and intracellular processes. In particular, carbohydrates are important mediators of cell–cell recognition events and have been implicated in related processes such as cell signaling regulation, cellular differentiation and immune response. This diverse utility has long suggested the power of carbohydrates in therapeutic approaches. This Concepts article highlights the recent potential uses of glycoconjugates as therapeutics, with particular reference to glycopeptides, glycoproteins, glycodendrimers, and glycoarrays.