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Synthetic Applications of β‐Fluoroalkylated α,β‐Unsaturated Carbonyl Compounds
Author(s) -
Billard Thierry
Publication year - 2006
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500466
Subject(s) - moiety , carbonyl group , selectivity , chemistry , combinatorial chemistry , reactivity (psychology) , molecule , organic chemistry , stereochemistry , catalysis , medicine , alternative medicine , pathology
β‐Fluoroalkylated α,β‐unsaturated carbonyl compounds constitute efficient building blocks for the synthesis of complex fluorinated compounds. As the fluorinated moiety generally increases their reactivity, it also brings important modifications which can change the chemical behavior and selectivity. Their use has been already largely demonstrated. Nevertheless, the synthetic potential has not yet been fully explored and, consequently should play an important role in the design of new sophisticated fluorinated molecules. Nevertheless, it shall be important to develop new synthetic methods to enlarge their availability and their diversity.