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Group‐Selective Ring‐Closing Enyne Metathesis
Author(s) -
Maifeld Sarah V.,
Lee Daesung
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500407
Subject(s) - enyne metathesis , metathesis , steric effects , ring closing metathesis , ring (chemistry) , enyne , bicyclic molecule , combinatorial chemistry , chemistry , selectivity , diene , stereochemistry , catalysis , organic chemistry , natural rubber , polymerization , polymer
The ring‐closing metathesis (RCM) of dienynes represents a powerful methodology for the construction of mono‐ and bicyclic systems containing 1,3‐diene functionality. Despite its synthetic potential, the utility of dienyne RCM is significantly reduced due to poor group selectivity. To circumvent this shortcoming, several strategies utilizing steric hindrance, electronic variation, relay metathesis and ring‐closure kinetics have been implemented to exert control over the reaction pathways. This article highlights a variety of methods to achieve group‐selective enyne RCM of dienynes.