High Resolution 1 H NMR Structural Studies of Sucrose Octaacetate in Supercritical Carbon Dioxide

High pressure (HP), high resolution (HR), proton nuclear magnetic resonance ( 1 H NMR) spectroscopy has been utilized for the first time to investigate the solution structure of a carbohydrate based system, sucrose octaacetate (SOA), in supercritical CO 2 . The studies indicate that the average solution state conformation of the α‐ D ‐Glucopyranosyl ring of SOA in scCO 2 medium is consistent with the 4 C 1 chair form, while the β‐ D ‐fructofuranosyl ring adopts an envelope conformation. The investigations also suggest that scCO 2 is a promising medium to study the solution structure and conformation of acetylated sugar systems. Spectral manifestations of a specific interaction between the acetate methyl protons and CO 2 molecules are also presented.