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Solution‐ and Solid‐Phase Synthesis of Radicicol (Monorden) and Pochonin C
Author(s) -
Barluenga Sofia,
Moulin Emilie,
Lopez Pilar,
Winssinger Nicolas
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200500160
Subject(s) - solid phase synthesis , reagent , phase (matter) , chemistry , combinatorial chemistry , nuclear magnetic resonance spectroscopy , modular design , stereochemistry , organic chemistry , computer science , biochemistry , peptide , operating system
A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer‐bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.