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Cover Picture: Efficient and Mild Copper‐Catalyzed N‐ and C‐Arylations with Aryl Bromides and Iodides (Chem. Eur. J. 22/2004)
Author(s) -
Cristau HenriJean,
Cellier Pascal P.,
Spindler JeanFrancis,
Taillefer Marc
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200490074
Subject(s) - catalysis , aryl , nucleophile , copper , chemistry , combinatorial chemistry , chelation , cover (algebra) , organic chemistry , engineering , mechanical engineering , alkyl
The cover picture shows the very broad application field of new catalytic systems for the N‐, O‐ and C‐arylations of various nucleophiles (the background represents crystals of the catalyst Cu 2 O). These systems, which result from combinations of copper salts with a set of original chelating ligands not previously known to promote such reactions, are unique in terms of versatility. Mildness, low‐cost, experimental simplicity, and the ability to work at low catalyst loading are features of this methodology, which make it particularly well suited for industrial‐scale syntheses for which financial and environmental issues are of greater concern. Consequently, it should find applications very soon for the synthesis of industrially important synthetic targets, found in a range of pharmaceuticals, agrochemicals and natural products. For mote details see the article by M. Taillefer, H.‐J. Cristau et al. on p. 5607 ff.