Premium
Cover Picture: Towards Organo‐Click Chemistry: Development of Organocatalytic Multicomponent Reactions Through Combinations of Aldol, Wittig, Knoevenagel, Michael, Diels–Alder and Huisgen Cycloaddition Reactions (Chem. Eur. J. 21/2004)
Author(s) -
Ramachary Dhevalapally B.,
Barbas Carlos F.
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200490071
Subject(s) - chemistry , cycloaddition , click chemistry , michael reaction , aldol reaction , knoevenagel condensation , organic chemistry , reagent , grubbs' catalyst , organocatalysis , wittig reaction , combinatorial chemistry , catalysis , metathesis , polymerization , enantioselective synthesis , polymer
The cover picture shows a perspective of organo‐click chemistry depicting the bringing together of simple reagents, and amino acid and copper/copper sulfate catalysts to produce spirotriones, which are antioxidant compounds. Unlike conventional methods, organo‐click chemistry produces stereospecific products with very good yields in a single operation. Multicomponent reactions catalyzed by amino acids and copper sulfate together with simple reagents depicted here support the potential of a rich variety of chemistries available to the prebiotic world and beyond. For more information see the article by D. B. Ramachary and C. F. Barbas III on p. 5323 ff. The picture was designed by Michael Pique at the Scripps Research Institute.