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Synthesis of Water‐Soluble, Multiple Functionalizable Dendrons for the Conversion of Large Dendrimers or Other Molecular Objects into Potential Drug Carriers
Author(s) -
Müller Stephan,
Schlüter A. Dieter
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200401078
Subject(s) - dendrimer , combinatorial chemistry , fluorescence , water soluble , chemistry , surface modification , denticity , nanotechnology , polymer chemistry , materials science , organic chemistry , physics , crystal structure , quantum mechanics
The synthesis of dendrons and dendrimers which carry OEG chains and bidentate ligands and/or fluorescence tags is described. The orthogonally protected functional groups of the dendrons allow modification of the substitution pattern and attachment to larger entities. Both dendrons and dendrimers are highly water‐soluble. The dendrons should have considerable potential to convert, for example, commercially available, high‐generation dendrimers into water‐soluble, versatile support materials for antitumor therapy.