An Expedient Synthesis of the Repeating Unit of the Acidic Polysaccharide of the Bacteriolytic Complex of Lysoamidase | Zendy

Litjens Remy E. J. N. | Zendy; den Heeten René | Zendy; Timmer Mattie S. M. | Zendy; Overkleeft Herman S. | Zendy; van der Marel Gijsbert A. | Zendy

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An Expedient Synthesis of the Repeating Unit of the Acidic Polysaccharide of the Bacteriolytic Complex of Lysoamidase

Author(s) -

Litjens Remy E. J. N.,

den Heeten René,

Timmer Mattie S. M.,

Overkleeft Herman S.,

van der Marel Gijsbert A.

Publication year - 2005

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200400862

Subject(s) - polysaccharide , unit (ring theory) , chemistry , combinatorial chemistry , computer science , biochemistry , mathematics , mathematics education

The first synthesis of the trisaccharide repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase is presented. The construction is based on a linear glycosylation strategy that starts from the reducing end and employs thio‐ and selenoglycosides in a highly stereoselective manner by a single set of activation conditions. The thus‐formed trisaccharide is selectively deprotected and oxidised, after which a final deprotection step furnishes the desired repeating unit.

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