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Towards Enantioselective Nucleophilic Trifluoromethylation
Author(s) -
Roussel Solveig,
Billard Thierry,
Langlois Bernard R.,
SaintJames Laurent
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200400777
Subject(s) - trifluoromethylation , enantioselective synthesis , nucleophile , chemistry , organic chemistry , combinatorial chemistry , catalysis , trifluoromethyl , alkyl
Various trifluoroacetamides and trifluoromethanesulfinamides, derived from chiral silylated amino alcohols, have been synthesized with the goal of achieving enantioselective nucleophilic trifluoromethylation. The best results were obtained with ( R )‐phenylglycinol derivatives, but the ee values did not exceed 30 %.
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