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A Modular Approach to DNA‐Programmed Self‐Assembly of Macromolecular Nanostructures
Author(s) -
Gothelf Kurt V.,
Brown Raymond S.
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200400646
Subject(s) - dna , macromolecule , nanotechnology , modular design , polymerization , conjugated system , covalent bond , dna nanotechnology , dna origami , chemistry , coupling (piping) , materials science , combinatorial chemistry , nanostructure , computer science , polymer , organic chemistry , biochemistry , metallurgy , operating system
DNA‐programmed organic reactions are new and powerful tools for assembling chemical compounds into predetermined complex structures and a brief review of their use is given. This approach is particular efficient for the selection and covalent coupling of multiple components. DNA‐templated synthesis is used for polymerization of PNA tetramers and for copying of the connectivity information in DNA. Direct DNA‐programmed multicomponent coupling of custom designed organic modules is described. The macromolecular structures obtained are highly conjugated potentially conducting nanoscaffolds. Some future developments in this area are discussed.