Premium
Towards Organo‐Click Chemistry: Development of Organocatalytic Multicomponent Reactions Through Combinations of Aldol, Wittig, Knoevenagel, Michael, Diels–Alder and Huisgen Cycloaddition Reactions
Author(s) -
Ramachary Dhevalapally B.,
Barbas Carlos F.
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200400597
Subject(s) - knoevenagel condensation , wittig reaction , aldol reaction , cycloaddition , chemistry , enantioselective synthesis , organocatalysis , michael reaction , organic chemistry , malononitrile , diels–alder reaction , aldehyde , combinatorial chemistry , catalysis
Here we report on our studies on combinations of amino acids and copper( I ) for catalyzing multicomponent reactions (MCRs). We aimed to prepare both diene and dienophiles simultaneously, under very mild and environmentally friendly conditions, thus giving the constituents for a stereocontrolled Diels–Alder reaction, which in turn yields compounds 4 to 8 . A diversity‐oriented synthesis of polysubstituted spirotriones 4 to 6 were assembled from simple substrates like 1‐(triphenylphosphanylidene)‐propan‐2‐one, two aldehydes, and cyclic‐1,3‐diketones through Wittig/Knoevenagel/Diels–Alder and aldol/Knoevenagel/Diels–Alder reaction sequences in one pot under stereospecific organocatalysis. Chemical diversity libraries of polysubstituted spirotrione‐1,2,3‐traizoles 8 were assembled from simple substrates by means of Wittig/Knoevenagel/Diels–Alder/Huisgen cycloaddition reaction sequences in one pot under stereospecific organo/Cu I catalysis. Functionalized dispirolactones such as 6 are biologically active antioxidants and radical scavengers, and spirotrione‐1,2,3‐traizoles 8 have found wide applications in chemistry, biology, and materials science. Experimentally simple and environmentally friendly, organocatalytic, asymmetric four‐component Diels–Alder (AFCDA) reactions of 1‐(triphenylphosphanylidene)‐ propan‐2‐one, two different aldehydes, and cyclic‐1,3‐diketones produced diastereospecific and highly enantioselective substituted spirotriones 4 by means of a Wittig/Knoevenagel/Diels–Alder reaction sequence in one pot. Additionally we have developed an organocatalytic, asymmetric three‐component Michael (ATCM) reaction of 1‐(triphenylphosphanylidene)‐propan‐2‐one, aldehyde, and cyclic‐1,3‐diketones that produced Michael adducts 15 , 16 through a Wittig/Michael reaction sequence in a highly enantioselective one‐pot process.