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Novel Rhodium‐Catalyzed Reaction of Thiazolidine Derivatives with Carbodiimides
Author(s) -
Zhou HaiBing,
Dong Chune,
Alper Howard
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200400543
Subject(s) - rhodium , thiazolidine , regioselectivity , imine , chemistry , catalysis , combinatorial chemistry , ring (chemistry) , organic chemistry
A new, simple, and regioselective synthesis of thiazolidinimine derivatives based on the rhodium‐catalyzed reaction of readily available thiazolidines with carbodiimides is described. This methodology provides direct access to a large variety of thiazolidinimine derivatives, possibly via a novel regiospecific insertion of carbodiimides into one of two ring carbon–nitrogen bonds, as well as a metal‐catalyzed imine elimination process.