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Novel Carboranyl C ‐Glycosides for the Treatment of Cancer by Boron Neutron Capture Therapy
Author(s) -
Tietze Lutz F.,
Griesbach Ulrich,
Schuberth Ingrid,
Bothe Ulrich,
Marra Alberto,
Dondoni Alessandro
Publication year - 2003
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200390148
Subject(s) - glycoside , boron , neutron capture , chemistry , cancer therapy , cancer treatment , cytotoxicity , cancer , organic chemistry , pharmacology , combinatorial chemistry , medicine , biochemistry , in vitro
The synthesis of the novel unprotected carboranyl C ‐glycosides 2 and 20 – 24 starting from ethynyl C ‐glycosides 1, 5 – 8, 10 , and 13 is described. The new compounds are highly water‐soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer.