Premium
Multi‐Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C
Author(s) -
Storer R. Ian,
Takemoto Toshiyasu,
Jackson Philip S.,
Brown Dearg S.,
Baxendale Ian R.,
Ley Steven V.
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200305669
Subject(s) - reagent , chemistry , combinatorial chemistry , natural product , stereoselectivity , aqueous solution , catalysis , chromatography , organic chemistry
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer‐supported reagents, catalysts, scavengers and catch‐and‐release techniques to avoid frequent aqueous work‐up and chromatographic purification.