Premium
Nonswelling Macroporous Synbeads for Improved Efficiency of Solid‐Phase Biotransformations
Author(s) -
Basso Alessandra,
Braiuca Paolo,
De Martin Luigi,
Ebert Cynthia,
Gardossi Lucia,
Linda Paolo,
Verdelli Silvia,
Tam Andrea
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200305243
Subject(s) - porosity , swelling , biocatalysis , catalysis , polymer , materials science , chemical engineering , phase (matter) , chemistry , organic chemistry , reaction mechanism , composite material , engineering
An application of novel, highly porous nonswelling resins (Synbeads) for enzymatic catalysis on solid supports is reported. These new resins combine easy handling of the beads, chemical stability, improved accessibility of proteins and higher productivity relative to swelling polymers. The present study demonstrates that the resin porosity greatly affects the efficiency in solid‐phase biotransformations and that Synbead resins are valuable alternatives to swelling polymers for solid‐phase chemistry and biocatalysis. The present study investigates the influence of key parameters, such as porosity and reactive functional‐group density, on the reaction efficiency.