Premium
Structure Investigation of Ti IV ‐BODOLates Involved in the Catalytic Asymmetric Reduction of Ketones Using Catecholborane
Author(s) -
Sarvary Ian,
Norrby PerOla,
Frejd Torbjörn
Publication year - 2004
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200305202
Subject(s) - catalysis , chemistry , titanium , nuclear magnetic resonance spectroscopy , medicinal chemistry , crystallography , stereochemistry , organic chemistry
Abstract The complexes formed by the reaction of [Ti(O i Pr) 4 ] and bicyclo‐octanediols (BODOLs) 1 and 2 (1:1) are useful as chiral catalysts in asymmetric reductions and were investigated by 1 H NMR spectroscopy and computational methods. A consistent picture emerged of head‐to‐tail dimers being kept together via a Ti‐O‐Ti‐O μ‐oxo bridge similar to the Ti‐tartrates but different from the corresponding Ti‐BINOLates and Ti‐TADDOLates.