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Mild Synthesis of Polyfunctional Benzimidazoles and Indoles by the Reduction of Functionalized Nitroarenes with Phenylmagnesium Chloride
Author(s) -
Dohle Wolfgang,
Staubitz Anne,
Knochel Paul
Publication year - 2003
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200305090
Subject(s) - phenylmagnesium bromide , nitrene , chemistry , chloride , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , reagent
Abstract Phenylmagnesium chloride has been used for the conversion of selected nitroarenes into nitrenes. Their insertion into a neighboring sp 2 CH bond yielded functionalized heterocycles. A novel and mild synthesis of polyfunctional benzimidazoles and indoles is described.