Enantioselective Borohydride Reduction Catalyzed by Optically Active Cobalt Complexes

The highly enantioselective borohydride reduction of aromatic ketones or imines to the corresponding alcohols was developed in the presence of a catalytic amount of an optically active cobalt( II ) complex catalyst. This enantioselective reduction is carried out using a precisely premodified borohydride with alcohols such as tetrahydrofurfuryl alcohol, ethanol and methanol. High optical yields are obtained by choosing the appropriate alcohol as modifiers and a suitable β ‐ketoiminato ligand of the catalyst. The enantioselective borohydride reduction has been successfully applied to the preparation of optically active 1,3‐diols, the stereoselective reduction of diacylferrocenes, and dynamic and/or kinetic resolution of 1,3‐dicarbonyl compounds.