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Phospholipase A 2 Hydrolysis of Mixed Phospholipid Vesicles Formed on Polyelectrolyte Hollow Capsules
Author(s) -
Ge Liqin,
Möhwald Helmuth,
Li Junbai
Publication year - 2003
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200304315
Subject(s) - polyelectrolyte , phospholipid , vesicle , hydrolysis , chemistry , chemical engineering , chromatography , biophysics , membrane , biochemistry , organic chemistry , polymer , biology , engineering
Mixtures of the phospholipids L ‐ α ‐dimyristoylphosphatidic acid (DMPA) and L ‐ α ‐dipalmitoylphosphatidylcholine (DPPC) have been successfully adsorbed onto the charged surface of multilayer polyelectrolyte capsules to form a novel vesicle. Leaving such vesicles in phospholipase A 2 solution, we observed the hydrolysis reaction on the surface of the lipid/polymer vesicles and a permeability change before and after the reaction by confocal‐laser scanning microscopy (CLSM). A capsule with adjustable permeability was constructed. This method may provide new features for drug‐release vesicles.