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Chiral [RuCl 2 (dipyridylphosphane)(1,2‐diamine)] Catalysts: Applications in Asymmetric Hydrogenation of a Wide Range of Simple Ketones
Author(s) -
Wu Jing,
Ji JianXin,
Guo Rongwei,
Yeung ChiHung,
Chan Albert S. C.
Publication year - 2003
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200204688
Subject(s) - catalysis , enantioselective synthesis , substrate (aquarium) , diamine , combinatorial chemistry , asymmetric hydrogenation , scope (computer science) , chemistry , noyori asymmetric hydrogenation , ketone , simple (philosophy) , organic chemistry , computer science , oceanography , programming language , geology , philosophy , epistemology
The dipyridylphosphane/diamine–Ru complex combined with t BuOK in 2propanol acts as a very effective catalyst system for the enantioselective hydrogenation of a diverse range of simple ketones including heteroaromatic ketones, substituted benzophenones, alkenyl ketones, and cyclopropyl ketones. The combination of desirable features, such as quantitative chemical yields within hours, broad substrate scope, excellent enantioselectivities (up to 99 %), and high substrate‐to‐catalyst ratios, among others, makes the present catalyst system of high practical interest.